Images taken meters from the explosion shows a huge ball of fire towering into the Saturday night sky.
Traffic on the main Accra Central to Aburi road has been diverted as firefighters battle the raging fire.
Reports indicate many casualties but Myjoyonline.com cannot independently verify this yet.
Hundreds of residents in and around Madina, Atomic Junction and a section of the main campus of the University of Ghana, Legon are said to have taken to their heels following the explosion that occurred at a gas station.
We are monitoring the situation and will bring you more details soon.